Monday, November 23, 2009

How the Liver Detoxifies Harmful Substances?

Basically there are TWO major detoxification pathways inside the liver cells, which are called the Phase 1 and Phase 2 detoxification pathways.

Phase One - Detoxification Pathway
An example of the phase one pathway is the Cytochrome P-450 mixed function oxidase enzyme pathway. These enzymes reside on the membrane system of the liver cells (called Hepatocytes).

Human liver cells possess the genetic code for many isoenzymes of P-450 whose synthesis can be induced upon exposure to specific chemicals. This provides a mechanism of protection from a wide variety of toxic chemicals. Read more...

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