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Saturday, February 20, 2010
Prostate Cancer Screening: 50 Percent False Positives
Over-diagnosis refers to the detection of a cancer that, if left untreated, would never have any negative effects on a person's life. This happens with cancers that grow slowly and do not spread to other organs, so that a patient dies of other causes before ever experiencing any symptoms.
Because prostate cancers tend to be very slow growing, the U.S. Preventive Services Task Force has recommended against screening men over the age of 74 for prostate cancer. Treatments for the disease can have severe side effects, including impotence and incontinence, and may even increase the risk of early death.
Another paper, published in the same issue of the journal, found that the prostate specific antigen (PSA) test commonly used to assess prostate cancer risk cannot reliably predict this risk in most cases.
The PSA is a marker of prostate inflammation, which in turn is believed to be a risk factor for prostate cancer. Yet in a study on 1,540 Swedish men, researchers found that PSA levels were not correlated with prostate cancer risk. The only exception was levels below 1 nanogram per mililiter, which suggest a prostate cancer risk of almost zero. Read more...
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